Agent Smith (Hugo Weaving):
"I'd like to share a revelation that I’ve had during my time here. It came to me when I tried to classify your species, and I realised that humans are not actually mammals. Every mammal on this planet instinctively develops a natural equilibrium with the surrounding environment; but you humans do not. Instead you multiply, and multiply, until every resource is consumed. The only way for you to survive is to spread to another area. There is another organism on this planet that follows the same pattern... a virus. Human beings are a disease, a cancer on this planet, you are a plague, and we... are the cure."
The Matrix (1999).
(Agent Smith, in the Matrix movies, is programmed to keep order within the system by terminating humans who would bring instability to the simulated reality, as well as any rogue programs that no longer serve a purpose to the machine collective. The number plate of Agent Smith's car in The Matrix Reloaded is IS 5416, which is a reference to Isaiah 54:16 in The Old Testatment, the source of Smith's name for the movie:
"Behold, I have created the Smith that bloweth the coals in the fire, and that bringeth forth an instrument for his work; and I have created the waster to destroy.")